Articles, announcements and insights from Horizon Discovery

Building complex human cell models for oncology research

Oct 10, 2016 11:20:51 AM No Comments

Background

Chromosome abnormalities are a characteristic feature of cancer cells. Translocations are large chromosome rearrangements which are key drivers of tumorigenesis and found in various tumour typesGene fusions result from balanced chromosome translocations and frequently lead to activation and overexpression of an oncogene. The nature of gene fusions strongly correlates with the tumour type, making them very attractive targets for cancer diagnostic or therapeutic intervention. 

Chromosomal translocations are triggered in vivo by the simultaneous occurrence of double strand breaks. The scientists at Horizon Discovery have recently published a new robust and precise approach to generating translocations. This advancement facilitates the generation of relevant cell line models for oncology research.  

 

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2016 Nobel Prize in Medicine Awarded to Autophagy Pioneer: Professor Yoshinori Ohsumi

Oct 10, 2016 9:42:14 AM No Comments

Recycling has always been a smart idea, and nature has its own processes to ensure that waste is kept to a minimum.  As Professor Ohsumi discovered, autophagy is the cells way of degrading and recycling cellular components, allowing it to adapt to nutritional deficiency or other environmental influences. Professor Yoshinori Ohsumi, honorary professor and leader of the Cell Biology Unit at the Tokyo Institute of Technology, has been studying autophagy for 27 years. This year's Nobel Laureate discovered and elucidated mechanisms underlying autophagy, according to the Press Release from The Nobel Assembly at Karolinska Institutet.

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