Articles, announcements and insights from Horizon Discovery

Efficient breeding of rat and mouse models

Apr 11, 2019 6:42:52 PM No Comments

5 keys to success for colony management

  • Direct access to the actual colony managers working with your colony
  • Dedicated project manager communicating key updates and timelines
  • Colony Management Software tracking your colony progress
  • Industry experienced animal technicians, colony managers, and reproductive scientists
  • Sophisticated IVC caging, comprehensive health monitoring, AAALAC & OLAW accreditations
Read More in vivo, animal model breeding

Patient derived xenograft (PDX) use in cancer research

Apr 18, 2018 11:59:19 AM No Comments


Due to obvious ethical considerations, cancer research conducted in humans is restricted to observational and analytical studies, with therapy focused clinical trials being the one exception to this rule. Preclinical mouse tumour models therefore provide a critical intermediate experimental model system tying together more basic in vitro research with studies in humans, thereby providing bench-to-bedside translational oncology research.

Read More PDX, in vivo, Patient Derived Xenografts, Oncology, Immunodeficient Mice

Turning The Lights On Inside Your Genetic Toolbox

Feb 20, 2018 3:06:58 PM No Comments

Optogenetics, a neuromodulation method that is employed to control and monitor the activities of individual neurons in living tissue and was first developed by researchers Edward Boyden and Karl Deisseroth in 20051, is now considered as being one of the main pillars of neuroscience research.

In 2010, the journal Nature Methods choose optogenetics as the ‘Method of the Year’2 across all fields of science and engineering. In the same year the academic research journal Science highlighted it in the article ‘Breakthroughs of the Decade’3. The basis of this technique is to genetically modify neurons to express light-sensitive ion channels such as excitatory channelrhodopsin or inhibitory halorhodospin and then use light to control the on/off status of neuronal excitation. Great progress has been made with this technology since its invention and today even conscious free-moving animal models can be manipulated and observed in real-time.

Read More Gene editing, Cre, in vivo, knock-in rats, Cre-LoxP

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