Articles, announcements and insights from Horizon Discovery

Patient derived xenograft (PDX) use in cancer research

Apr 18, 2018 11:59:19 AM No Comments

 

Due to obvious ethical considerations, cancer research conducted in humans is restricted to observational and analytical studies, with therapy focused clinical trials being the one exception to this rule. Preclinical mouse tumour models therefore provide a critical intermediate experimental model system tying together more basic in vitro research with studies in humans, thereby providing bench-to-bedside translational oncology research.

Read More PDX, in vivo, Patient Derived Xenografts, Oncology, Immunodeficient Mice

How to Cure Cancer in 3 Easy Steps

Mar 6, 2017 6:10:15 PM No Comments

When I have read articles just like this one early on in my career, I would laugh and categorize it with blogs regarding Bigfoot and the Loch Ness Monster. However, much has changed in the past 10 years. New technologies have been developed and milestones have been reached that should have Cancer a little worried. These 3 steps might be viewed to some as obvious, but I argue that it’s how the researchers have utilized the technology wisely that has made the difference. I have identified some papers that have carved a successful path to Cancer's possible demise.

Read More Cell lines, Gene editing, CRISPR, Oncology Panels, Target identification, Target validation, PDX, Cancer models, Preclinical efficay testing, High Fidelity Models

Patient Derived Xenografts:  The Crucial Piece for Curing Cancer

Jan 4, 2017 3:57:00 PM No Comments
Read More PDX, preclinical efficacy testing, Cancer models, High Fidelity Models

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